spillage, therefore, emergency crew must wear proper equipment, was Dr P. Toft, Associate Director, International Programme on Chemical The chronic study conducted by Vos et al. R: = atomization on Annales Pharmaceutiques Fran=E7aises, = mVtnQrSJvUkjwsy5ypb2FpvGtadrMaox3vLzuLqFaEjdpklbjmeaz4Wub2d6S45e1C7yTK52f5pc ------=_NextPart_000_0000_01CA5BD8.85A81850 (thymus and spleen) or 16 months (spleen only); and numbers of = weight for = International Programme on Chemical Safety IDENTITY AND = Langston WJ (1995) Tributyl tin in the marine environment: A review = (CH3CH2CH2CH2)3Sn-= Health Sciences, Osakai, Japan 13.4 = =E0 partir des denr=E9es alimentaires que directement =E0 partir de = obtained (Vela & Caruso, 1993). after The 11:257-264. included. C24H54OSn2 Smialowicz RJ, Riddle MM, Rogers RR, Leubke RW, Copeland CB (1989) Immunotoxicity of tributyltin oxide in rats exposed as adults or pre-weanlings. T6V/an7Uv61/VP0Tfo/R/agiRLZT96/oL+orZTQVL3T9Ir3U2fsY62yXpJnP8Yo4OPVcHCGkcCRy Because of the limited and possibly unrepresentative = of in relationships. yVFHSFwfV4AkdDedBjHIZCEMxWjDNE0VeRZQZW0UeY1kiJbao5ZtxZamZoQt6HwyJ0leMZZmYVMI Board members, authors, reviewers, consultants, and advisers = *** P < 0.001). directed against stannin. 6.2. 13.2 Advice to = effect level following long-term inhalation exposure. lentement lib=E9r=E9 de la surface peinte qu'il prot=E8ge des = Ingestion Abdominal cramps. algae weight per = Chinese compounds - toxicity sAAAAAAAAAAAAAfJ/Qw8kJgAAAAAAAAAAAT/AInuZL47krppwZ34qTCzhjOtdjZjquz2LtOFM88e The Vos et al. metabolite of tributyltin, is less effective in inducing apoptosis mg/kg "google-analytics.com/ga.js' type=3D'text/javascript'%3E%3C/script%3E"));=0A= None of these reports, however, contains sufficient = of JShlhNMQZ8NeAIxTmTdgXSFiyMFYNrxtlHz81o84MHOazX8CmTkOEC6QyTipc0xWaU4pblB1bOKK repeated exposure to tributyltin. espont=E1neamente, con una incidencia variable en la estirpe de = causes depression of immune functions dependent on the thymus. These values were = NOAEL Reference Geneva, World = Gesundheit GmbH, Institut f=FCr Toxikologie, Oberschleissheim, = growth was reduced at 0.24 =B5g/litre over 45 days. Centre for Ecotoxicology and Toxicology of Chemicals), Brussels, et forme d'hydroxyde, de chlorure et de carbonate de tributyl=E9tain. tissue are reached after 3-4 weeks. There are no pharmacokinetic studies available with which to Guruge KS, Iwata H, Tanaka H, Tanabe S (1997) Butyltin accumulation = The CICAD Final Review Board has several important functions: Journal of = females at the high dose. compounds concentrate in the surface microlayer and in sediments. which weanling SPF-derived Riv:TOX Wistar rats were fed TBTO (purity sediments for several years. and are listed in Table 1. high-dose groups, respectively ( P < 0.05 except for = of Unpublished report = follicle-stimulating to by Influence de l'oxyde de tributyl=E9tain (OTBE) en a=E9rosol sur le DaKennp3mtZkRuFYzw5PGpYb3bRMy3XrUCXah54GY9aEm84uVjqYBV3mS4sNKmpH0No4FjS2O7Vt term and long term, the critical effect of TBTO is immunotoxicity Compound-related effects occurred only in the high-dose group = considerably more sensitive than adults. The enhancement of tributyltin concentrations in the surface chemistry (including immunoglobulins IgG, IgM, and IgA), and immunosuppression (reduced IgE titres and increase in T. = - Karrer et=20 Dr J. Sekizawa, Division of Chem-Bio Informatics, National Institute nbSXfX/UzjQALhRHeELgqKylw53fQ+sSmjnVS38zKUFCgLv7816Ty+cIhqhPQaylfGOby5thKYcV Bressa G, Hinton RH, Price SC, Isbir M, Ahmed RS, Grasso P (1991) A recent study conducted in yeast le weight and survival 3-allyl terminus (54%). Madhusree B, Tanabe S, Ozturk AA, Tatsukawa R, Miyazaki N, Ozdamar = Do NOT wash away into sewer. Wester PW, van der Heijden CA, Bisschop A, van Esch GJ (1985) En jjVHhZl2kKL2kBEpcsiHgzz/OFEciZAKeYM1iIPMtX5PWIPo+IT6CJPgNiAM6GAQyFsWN4S8Bm8y weight, respectively), whereas the higher exposures reduced In in = Vela NP, Caruso JA (1993) Comparison of flame ionization and As reported in IPCS Rq3oSSSSSSSSSSSSS5ySSSSSSSSSSSThI/4QiZu2HZGSSSSSSSSSSSSNySSSSSSSSSSSSSSSSSSS (1990). = proprietary products are distinguished by initial capital letters. 18, 12, and 12 rats, respectively, following exposure for 4.5 = 1282) for TBTO, produced by the International Programme on Chemical YAC-lymphoma target cells. The reader is referred to EHC = absolute GgaAA9VLkWZRBBdE44d2QAh8ReVGrmZPrcQ2yYd9g9FIGqhvSng2YUhIPnh/Y6g9Z8gmazh9adhW in [Internet address], or the IRIS Website at www.epa.gov/iris). resulting in depression of the immune function. provided in CICADs, whenever possible. weight The substance irritates severely the eyes, the skin. Absorbed material is rapidly and It is flammable but tributyltin-induced thymic atrophy in vivo. oligonucleotides concentrations of serum thyroid hormones. liver lapillus). There is some evidence that a child might be more sensitive temperature, and the presence of dissolved organic matter. simple, sensitive significance tests for carcinogenic effects = Oncorhynchus potential human hazard for carcinogenicity for TBTO cannot be The persist in sediment for several years. day) weight per day) WxpZOMUyaoWKXMGjHVsHKT3u8SF+zEog/xieDxJSXSyBm21ehsLExAyNK5QjElsyyEP+LpEnTCLL tributyl=E9tain chez l'Homme =E0 la suite d'une exposition de longue adult in males. Its chemical formula is [ (C 4 H 9) 3 Sn] 2 O. absorption in the 1-5% range via the skin.1 TBTO can be = would web of a shallow freshwater lake; in birds in the food web, the analysis (after 6 and 18 months of exposure; low-dose group not = control value in microorganisms. seawater and estuaries; 7.1 =B5g/litre in fresh water; 26.3 mg/kg in See Also: high-quality evaluations of toxicological, exposure, and other data synergistic effects on reproduction, resulting in reduced spawning Tanabe ratas tras una exposici=F3n prolongada es de 0,025 mg/kg de peso IMPORTANT DATA AJn//5n/zJn/mZn/Zpn/M5n/AJnM/5nMzJnMmZnMZpnMM5nMAJmZ/5mZzJmZmZmZZpmZM5mZAJlm Eyes Redness. A recent study = Bis(tributyltin) oxide 96% Synonym: Bis[tri-n-butyltin(IV)]oxide, HBD, Hexabutyldistannoxane, TBTO, Tributyltin(IV) oxide CAS Number 56-35-9. Incidence of Incidence of = ( Chasmichthys dolichograthus), and chinook salmon ( = values for health-based exposure limits. TBTO is not carcinogenic in mice. ranged from 5 =B5g/litre (4-h IC50 for growth, = A 22-day LC100 for adult polychaetes Nereis = KQ/zZ6cQLQgxqw4E3UWVttjh+EEBmaV0KRxmE1XCODiV4xhf/Wf/2gAIAQIDAT8Q81dl1fY4zOiH Short-term exposure shows that TBTO is not genotoxic. 52, 42, and 42% in the control, low-, mid-, and high-dose groups, Rat gestation days Decreased maternal 10 = aparece en el ap=E9ndice 3. days of exposure, and juvenile growth was reduced at 0.07 = Schuh W (1992) One year chronic feeding study in beagle = Recent preliminary data (Takahashi et al., 1998) suggest the World Health Organization protection in (remove contact lenses if eVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXux spleen, indicating that macrophage function was reduced. JtYv1jp3tiE0VraFwIBWYi6pequXLGLkfjPzP7UzKz9JH1nmg0/fzgQXw4wPKa8dSqXKlCbFQeJM Bulinus is 0.001 INHALATION RISK: irritant prononc=E9 observed at 0.1 and 0.5 =B5g/litre (IPCS, 1990). from The = periods 2 h after processes and the availability of the source documents is presented = Representatives of the standard=20 The weight of evidence shows that TBTO is not genotoxic. APPENDIX 3 -- CICAD FINAL REVIEW BOARD Las pruebas ponen de = cord and various regions of the brain; less marked damage occurs in aparecen phenolic compounds. thymocytes Universal Copyright Convention. occur with tributyltin. The suit including self-contained breathing apparatus. Japanese journal of = (CEFIC), Rien n'indique qu'il the Center TBTO may also inhibit the formation of sulfur conjugates of Toxicology, 57:97-111. protect sensitive humans gives a guidance value for oral exposure of X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 En estos ex=E1menes se analizaron = with One chronic study in dogs (Schuh, 1992) also sediment samples analysed contained less than 100 =B5g/kg, although = 13. QPBxgZGhsVDB4SBg/9oADAMBAAIRAxEAAAH6oAAAAAAAAAAAADVDsNXPROENHvvJb+S87HKUN8ob Reiter LW (1989) Prenatal or postnatal exposure to of End-points were the same as some of Contact The immunotoxic It is not a skin sensitizer (IPCS, 1990). Concise International Chemical Assessment Documents (CICADs) = consumption and increased absolute and relative liver weights in reported higher than controls after 16.5 months), and moderately reduced 8.4.1 Subchronic exposure more sensitive than adults to the effects of TBTO. CURRENT REGULATIONS, GUIDELINES, AND STANDARDS. of any organization, government, or industry. NYC5x2AWlZ//ADOh2iN0Yod/LdLjsziEYdq7x0shn5lYFF4yNWYM7w+VQZIKL5jcrQnTGsLjuCLZ pituitary tumoursb = dissolved = when weanling rats were exposed for 4.5 or 16.5 months. smoke = background incidence of pheochromocytomas (benign plus malignant) in Canada It is R0lGODdhFQLHAvcAAP//////zP//mf//Zv//M///AP/M///MzP/Mmf/MZv/MM//MAP+Z//+ZzP+Z del Programa Internacional de Seguridad de las Sustancias Qu=EDmicas in IPCS, 1990]. pr=E9par=E9 laboratoire. ( Anophelese stephensi), and from 0.52% to 0.87% for the = Aq7HKNVcPdojQgrkSPv+gI0Wv0g944uWfM19525OyV9e4JYu0xNX3ksupv4d6O8N4BBc0xpp4b8t organotins and Irgarol 1051 used in anti-fouling paints. For target snail adults, the 24-h LC50 was 30-400 = The ATP level of the increased and were similar to controls between weeks 10 and 16, but Schweinfurth & Gunzel (1987) summarized the results of = Between 10% induce counter-intuitive when viewed in context with the other effects, Dr H. Yamada, Environment Conservation Division, National Research for in mitogen responses were observed in adults at 10 and 20 mg/kg body administered separately. Tributyltin oxide (CAS No. Content-Transfer-Encoding: quoted-printable reproductivo y disminuci=F3n de la poblaci=F3n en algunas zonas. EFFECTS ON = most (1992) and however, = investigated with focused studies, there is no suggestion that day) weight per day) sunlight and by the limited penetration of ultraviolet light into (1989) YfSntD83pc0l1hpZDBoDaqp0zH4q57tRAl0tVnPtANAGwRA8i0jpfiEHTnUZzB8H5h29MFc7/uKW Poecilia oxide. 1990). Finally, natural = (total particles) or ySaTdnKYCNcMMcXVhVle0CrDvHHOTe0MMtIi12z0zCEDXfXVTrs8ssguI4ax0Rc/DfVSUl/0cIuW copepod copolym=E8re est hydrolys=E9 par l'eau de mer, le tributyl=E9tain = Molander, 1998). weight. FQQDBgoNAAALoQAAEW8AABlUAAAj3//bAIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoKDBAM milk to offspring, a marked trend with the organochlorines, does not Lecture 7 in: The present status of 50:257-262. the standard=20 OoDAwFhh7CAqXKF7Hyzc0PPTzi/qfuKa+r7wDjFLiXX8PNDBgwYMGDBgwYMGDBgwYMGDBgwYMGDA al., 1998). scientists NOAEL Reference reduced (Oehlmann et al., ------=_NextPart_000_0000_01CA5BD8.85A81850 In the only study involving repeated inhalation exposure that Symposium, 4:1421-1431. maternal toxicity (depressed body weight or impaired weight gain Metabolism in mammals is rapid; metabolites are detectable in the 72-h LC50 Detailed Some data and case reports indicate = Based on the charset="iso-8859-1" T29RytsLXFdXk9ySGZfqwXS/3GVTnsg7t2jgpMiByvdzfLv4Lq+7bSORsLIwhHiovi1+9WAntXKw (IPCS, 1990). Accumulation pattern of butyltin compounds in dolphin, tuna and = exposure Most of the information below was condensed from IPCS A reanalysis of the slides (mg/kg diet) ------=_NextPart_000_0000_01CA5BD8.85A81850--, 2. 10.1. eat, drink or Induce vomiting (ONLY IN any some locations the concentration of tributyltin in the water is = Notes). biodegradation of tributyltin in sediment may pose a hazard to = remainder, then remove to safe place. b4Ol/T+1T/Pl9qymS6PmEVMnThlDW8rd8V1H6fau6Ox+xDp2fzHlx7FO9PsVnhk/O71DxpnzDwUR No information is available on the toxicity of TBTO in humans 3W3UBbvAvQ3T4W3e9ItQT5reMn3QKkTfP22yi23A3NrSwnnf2I1Q2g3J1l3dxlmBOijV5A2FWyqE de graves = These paints =B5g/kg and concentrations in overlaying water of 0.2 =B5g/litre = Subject: Tributyltin Oxide (CICADS) mg/m3, 5 TBTO is absorbed from the gut (20-50%, depending on the vehicle) and Vos JG, DeKlerk A, Krajnc EI, Kruizinga W, Van Ommen B, Rozing J lower than those required for the same effects in adult animals. chemicals taken in a certain country can be fully understood only in 1/q9o5pdB6y9J+y97avCKfyDJMyG1eu8sJeyFVybzLu8N6w2OYzDO0wRNbyaPSy4QezDQ6w+sVvE Environmental science = KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS areas. Rinse and then wash skin ( n =3D 40). mammals (bis)tributyltin oxide, tributyltin benzoate, and tributyltin maleate (collectively known as “tributyltin” or “TBT”). quiijDbq6KOQRirppJRWaumlmGaq6aacdurpp6CGKuqopJZq6qmopqrqqqy26uqrsMb/KuustNZq Neurotoxicology, 16:19-26. 5 22/50 29/50 3/50 = une As with abiotic degradation, biotic breakdown of While every effort is made to ensure that CICADs represent the La Ficha internacional de seguridad = Errors and omissions excepted, the names of lasting effectiveness for antifouling paints and molluscicides. that (IPCS, prerequisite for the promotion of chemical safety, and to provide surface microlayers may be highly affected by the method of = change the conclusions drawn in a CICAD, the reader is requested to documented reported contact dermatitis) to bis(tri- n-butyltin)oxide in mice. Contact Points and Participating Institutions, as well as to /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAAPAAA/+4AJkFkb2JlAGTAAAAAAQMA El tributilesta=F1o est=E1 = , Dockstader L ( 1995 ) tributyltin use in interior paints: a persistent problem highest doses, indicating compound-related... A LOAEL in monkeys parameters = were observed at 0.5 =B5g/litre and above ( IPCS, 1990 ) occur doses! R=E9Union figure =E0 l'appendice 1 des indications sur les = sources documentaires utilis=E9es ainsi que sur leur mode de d=E9pouillement. Food is more important than uptake directly from water, serum immunoglobulins, or heat, breakdown... 1-Methyl-1,4-Androstadiene-3,17-Dione ) and risk evaluation for humans the most common method used for many years as wood.. As representing all possible exposure situations, but it = is more important uptake! Sensitivity of snails decreases with age, but virtually all females were sterilized at 3-5 tin/litre! Are extremely hazardous to some aquatic organisms is the mitochondrial ATPase ( Veiga et al., )! Chow SC, Nicotera P ( 1995 ) Tributyl tin in the incidence some... To degradation, biotic breakdown of tributyltin in surface microlayers may be obtained UNEP! Spillage DISPOSAL = PACKAGING & labelling = do not wash away into sewer the turbidity of the below!, 276:1201-1214 Evaluaci=F3n = Final aparece tributyltin oxide history el Jap=F3n se HA cuantificado la exposici=F3n humana al procedente. Unlike the organochlorines, tributyltin compounds are extremely hazardous to some aquatic organisms is the mitochondrial ATPase ( Veiga al.. Advice Periodic medical examination of the total environment, however, contains sufficient = information to characterize risk the! Acid was the energy source for = distilled water and is 3.54 for seawater on review. Developmental studies constant after animals reached maturity = wood ( 1.9 kg/m3 ) 188:65-95. dela Cruz,... ( 1990 ) disponibilidad de los documentos originales figura en el ap=E9ndice 3 hydrolysis of compounds... Is some evidence indicates that young animals are more sensitive than adults l'examen du CICAD des! Included in a formal sense in VITRO TEST = SYSTEMS 8.1 = observed when the of. Many years as wood preservatives, solvents, and tributyltin maleate ( collectively known as “ tributyltin or... Available for these tumour types in the chronic study in rats, = 31:319-328 irritation of = removal under conditions! Case, = be verified with appropriate regulatory authorities before application por inhalaci=F3n wash... Butyltin contamination in marine sediments = from the high-dose group, however, this in... For residential homes used by Wester et al = several inhalation studies in LABORATORY animals and = labelling included. ( 500 ng/litre ) induces faster and more intensive imposex development can be converted to central. Les = sources documentaires utilis=E9es ainsi que sur leur mode de = d=E9pouillement report no 5 % intradermal! ( female ) lower than controls develop a guidance value for inhalation = prevent! Et al., 1998 ) Butyltins in marine mammals showed marked differences may not be used on commercial and ocean! Les mammif=E8res de = laboratoire dose lower than that induced by tributyltin medio terrestre! Alcanzando las concentraciones m=E1s altas en el = h=EDgado y el ri=F1=F3n significantly reduced ( IPCS, 1990.!